Original research
Cardiology
Original research relevant to this speciality, newest first.
- Early surgery is associated with better survival in asymptomatic severe primary mitral regurgitation
JAMA Network Open
Observational target-trial emulation, 802 patients. Surgery within six months was associated with lower mortality, HR 0.69; residual confounding remains possible. - Apixaban shows the most favourable anticoagulation balance in disabled nursing-home residents with atrial fibrillation
JAMA Network Open
Observational study, 26,940 residents. Anticoagulants were associated with fewer strokes but more major bleeding; apixaban had the most favourable profile among those studied. - Iatrogenic menopause before age 45 is associated with increased cardiovascular and overall mortality
JAMA Network Open
Meta-analysis, 36 studies and approximately 2.6 million women. Cardiovascular morbidity was elevated; mortality excess was concentrated in earlier menopause. - Orforglipron meets cardiovascular noninferiority versus insulin glargine in high-risk type 2 diabetes
The Lancet
ACHIEVE-4 phase 3 trial, 2,749 patients. Cardiovascular events: 4.2% versus 5.0%, HR 0.84. This establishes noninferiority, not cardiovascular superiority. - Escitalopram and amitriptyline prolonged QTc, but trials detected no increase in early major cardiovascular events with antidepressants.
BMJ
- Atenolol was associated with fewer cardiovascular events than bisoprolol after MI without recorded heart failure.
NEJM Evidence
- Higher blood pressure, older age and tenecteplase dose were linked to intracranial bleeding after STEMI thrombolysis.
European Heart Journal
- Carotid revascularization did not improve cognition beyond intensive medical treatment.
JAMA
- Whole grains modestly improved LDL cholesterol and other cardiometabolic risk factors.
European Heart Journal
- Catheter-directed thrombolysis reduced early deterioration in intermediate-high-risk pulmonary embolism.
NEJM
- Omitting aspirin from initial low-dose prasugrel treatment in STEMI failed to demonstrate noninferior ischaemic protection.
NEJM
- Clopidogrel alone after 12 months of coronary stenting reduced bleeding but increased ischaemic events in high-risk patients.
NEJM
- A default prasugrel policy did not reduce ischaemic events versus ticagrelor after PCI for acute coronary syndrome.
NEJM
- Potent P2Y12 inhibitors with a DOAC raised bleeding concerns in AF with acute coronary syndrome.
Nature Medicine
- Atorvastatin reduced cardiovascular events in healthy adults aged ≥70, without improving disability-free survival.
NEJM
- DOAC therapy reduced net adverse clinical events in AF with one non-sex stroke-risk factor.
NEJM
- Eplontersen did not significantly reduce cardiovascular death or recurrent events in transthyretin amyloid cardiomyopathy.
NEJM
- Shorter, response-guided antibiotics increased treatment-free days in stable endocarditis but increased relapse.
NEJM