Original research
Critical Care
Original research relevant to this speciality, newest first.
- Pulse corticosteroids show no clear survival advantage in acute exacerbations of idiopathic pulmonary fibrosis
American Journal of Respiratory and Critical Care Medicine
SAFER randomized trial, 100 patients. No significant 28- or 90-day mortality benefit; estimates were imprecise. Compared two steroid regimens, not steroids against no steroids. - Lower blood-pressure targets reduce vasopressor exposure in critically ill children
JAMA
RCT, 1,900 children. Vasopressor exposure fell, but the primary outcome combining mortality and ventilation duration did not significantly improve. - Therapeutic anticoagulation did not significantly reduce death or thrombosis in HERO-19.
JAMA Network Open
Small RCT, 139 hospitalised COVID-19 patients. HR 0.74, 95% CI 0.38–1.48; uncertainty remains substantial. - Starting with 30% oxygen rather than air did not reduce respiratory support in moderately preterm infants.
JAMA
- Catheter-directed thrombolysis reduced early deterioration in intermediate-high-risk pulmonary embolism.
NEJM
- Head elevation after thrombectomy did not significantly improve functional recovery compared with lying flat.
BMJ