Original research
Geriatrics
Original research relevant to this speciality, newest first.
- Earlier disclosure of Alzheimer blood biomarkers improves diagnostic confidence and changes management
JAMA Neurology
Randomized trial, 220 participants. High-confidence diagnoses at three months: 50.0% versus 4.6%. Improved long-term patient outcomes remain unproven. - Apixaban shows the most favourable anticoagulation balance in disabled nursing-home residents with atrial fibrillation
JAMA Network Open
Observational study, 26,940 residents. Anticoagulants were associated with fewer strokes but more major bleeding; apixaban had the most favourable profile among those studied. - Robotic hip replacement shows no overall implant-survival advantage over conventional surgery
The BMJ
Registry target-trial emulation, 666,283 procedures. Matched five-year implant survival was 98.8% in both groups; malposition-related revisions were lower with robotics. - RSV vaccination was associated with substantially fewer hospitalizations in older adults.
JAMA Network Open
- Atorvastatin reduced cardiovascular events in healthy adults aged ≥70, without improving disability-free survival.
NEJM