Original research
Hematology
Original research relevant to this speciality, newest first.
- Tirabrutinib produces responses in relapsed or refractory primary CNS lymphoma
Blood
PROSPECT single-arm phase 2 trial, 48 patients. Overall response 67%; complete response 44%. No control group; one treatment-related fatal infection occurred. - Young stroke survivors receiving antithrombotic therapy faced substantial long-term bleeding risk.
JAMA Network Open
ODYSSEY cohort, 1,226 patients: five-year bleeding risk 10.7%. Bleeding and recurrent vascular events differ in severity; this does not establish that stopping treatment is beneficial. - Therapeutic anticoagulation did not significantly reduce death or thrombosis in HERO-19.
JAMA Network Open
Small RCT, 139 hospitalised COVID-19 patients. HR 0.74, 95% CI 0.38–1.48; uncertainty remains substantial. - Intravenous iron improved haemoglobin and reduced transfusion compared with oral iron in pregnancy.
JAMA Network Open
Meta-analysis of 29 RCTs, 11,771 participants. Transfusion RR 0.63; haemoglobin at delivery approximately 0.59 g/dL higher. - Preoperative intravenous iron reduced transfusions and modestly improved recovery after cardiac surgery in patients with anaemia.
BMJ
- Intravenous arginine did not shorten sickle-cell pain crises in children and young adults.
JAMA
- Daily zinc reduced infections in a small trial of young children with sickle-cell anaemia.
JAMA
- Platelets refrigerated for up to 21 days were noninferior to standard platelets for bleeding during cardiac surgery.
JAMA
- Aspirin alone was noninferior to rivaroxaban followed by aspirin after hip or knee replacement.
NEJM