Original research
Neurology
Original research relevant to this speciality, newest first.
- Earlier disclosure of Alzheimer blood biomarkers improves diagnostic confidence and changes management
JAMA Neurology
Randomized trial, 220 participants. High-confidence diagnoses at three months: 50.0% versus 4.6%. Improved long-term patient outcomes remain unproven. - Starting ocrelizumab earlier preserves a disability benefit over ten years
JAMA Neurology
OPERA trial extension. Confirmed disability progression was lower with immediate versus two-year-delayed initiation: HR 0.76. Long-term follow-up was open-label with attrition. - Tirabrutinib produces responses in relapsed or refractory primary CNS lymphoma
Blood
PROSPECT single-arm phase 2 trial, 48 patients. Overall response 67%; complete response 44%. No control group; one treatment-related fatal infection occurred. - Implanted radiation tiles improve local control after brain-metastasis surgery
Journal of Clinical Oncology
Phase 3 RCT. Better surgical-bed recurrence outcomes than postoperative stereotactic radiation; no established overall-survival benefit. - Young stroke survivors receiving antithrombotic therapy faced substantial long-term bleeding risk.
JAMA Network Open
ODYSSEY cohort, 1,226 patients: five-year bleeding risk 10.7%. Bleeding and recurrent vascular events differ in severity; this does not establish that stopping treatment is beneficial. - Pregnancy hypertension marked later dementia risk, but the association weakened after accounting for subsequent vascular disease.
JAMA Network Open
Korean cohort of 1.37 million women. Adjusted HR fell from 1.96 to 1.15, becoming nonsignificant after additional adjustment. Few dementia events warrant caution. - Carotid revascularization did not improve cognition beyond intensive medical treatment.
JAMA
- Adding IVIG to prednisone improved early recovery in newly diagnosed inflammatory myopathy.
JAMA Neurology
- Febrile seizures were generally associated with minimal differences in later school performance.
JAMA Network Open
- Loberamisal improved stroke recovery in a Chinese phase 3 trial.
JAMA
- Oveporexton improved wakefulness and reduced cataplexy in narcolepsy type 1.
NEJM
- Head elevation after thrombectomy did not significantly improve functional recovery compared with lying flat.
BMJ
- Thrombectomy did not improve recovery in medium or distal vessel stroke and caused more symptomatic haemorrhage.
JAMA
- Rituximab was noninferior to ocrelizumab for MRI disease control in newly diagnosed relapsing multiple sclerosis.
NEJM