Original research
Rheumatology
Original research relevant to this speciality, newest first.
- Pausing selected arthritis treatments for COVID vaccination increases flares without improving antibody responses
JAMA Internal Medicine
COVER randomized trial, 840 patients. A two-week interruption increased flares. Applies to the studied biologics and JAK inhibitors. - Chronic immune-related toxicity affects nearly half of patients receiving adjuvant anti–PD-1 for melanoma
JAMA Network Open
Multicentre cohort, 303 patients. Chronic adverse events occurred in 48%, supporting continued monitoring after treatment ends. - Garetosmab reduces new heterotopic bone lesions in fibrodysplasia ossificans progressiva
The Lancet
Phase 3, 63 adults. One and two new lesions in the active-dose groups versus 19 with placebo at 56 weeks. Small trial in an ultrarare disease. - Tacrolimus and mycophenolate show no significant difference in sustained lupus-nephritis response
Kidney International
RCT, 130 patients, both with glucocorticoids. Response at 96 weeks 58.5% versus 69.2%; differing adverse effects. Absence of significance does not establish equivalence. - Adding IVIG to prednisone improved early recovery in newly diagnosed inflammatory myopathy.
JAMA Neurology