Original research
Urology
Original research relevant to this speciality, newest first.
- Urine cell-free RNA shows promise for bladder cancer detection and treatment-response prediction
Nature Medicine
Diagnostic biomarker study, 683 urine samples. Localized cancer detection achieved 95% sensitivity at 90% specificity. Prospective clinical-utility validation is needed. - Gepotidacin improves uncomplicated UTI symptoms within 24 hours in many patients
JAMA Network Open
Single-arm phase 3b study. 54.4% had symptom improvement at 24 hours; no comparator to establish superiority. - Five-fraction prostate radiotherapy improved bowel-related quality of life but was not superior for cancer control.
JAMA
- Perioperative enfortumab vedotin–pembrolizumab improved survival over cisplatin–gemcitabine in cisplatin-eligible muscle-invasive bladder cancer.
NEJM
- Adding belzutifan to adjuvant pembrolizumab improved disease-free survival after kidney cancer surgery but increased severe toxicity.
NEJM