Systemic lupus erythematosus in 2026
The GLADEL–PANLAR update separates mild skin and joint disease from moderate-to-severe disease and sets out combination regimens for proliferative lupus nephritis.
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Browse every research update, guideline, clinical review and feature, ordered by publication date.
Browse our summaries and reviews by specialty →51 articles
AHA 2026: Eight Selected Studies and What They Mean for Clinical Practice
A clinical roundup of OSA treatment, AI echocardiography, pacing and cardiovascular prevention—with the trial populations, results and evidence limits kept in view.
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Autoimmune haemolytic anaemia: from diagnosis to early treatment
A practical reading of the 2026 AustrAIHANZ consensus on confirming immune haemolysis, urgent transfusion and early steroid-sparing treatment for warm AIHA.
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Intensive blood-pressure control after ischaemic stroke or TIA: interpreting OPTIMAL-STROKE
Cardiovascular benefit and a renal safety signal with systolic targets below 120 versus below 140 mmHg: a clinical interpretation of the full OPTIMAL-STROKE trial.
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Resuscitation in 2026: Three Adult CPR Updates Worth Knowing
What changed in measured tidal volume, adult ventilation bag size and routine fluid use—and the exceptions and evidence limits that matter.
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Sodium Bicarbonate in ICU Metabolic Acidosis: Less RRT, but No Clear Survival Benefit
A Bayesian synthesis of four randomised trials suggests a high probability of reducing renal replacement therapy initiation, without establishing a short-term mortality benefit.
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Acute-on-Chronic Liver Failure in 2026: A Practical Summary of the Global Multisociety Consensus
The new shared ACLF definition, organ-dysfunction grades and bedside priorities for recognising deterioration, treating precipitants and assessing transplant candidacy.
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Contrast Media and Kidney Disease in 2026
How the Austrian radiology–nephrology consensus approaches iodinated contrast, hydration, medication review and low-risk gadolinium agents.
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Management of Right Heart Failure in 2026
A practical reading of the HFSA scientific statement: assess congestion and perfusion, identify the cause and tailor treatment to right ventricular physiology.
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Medical Mnemonics: Remember More. Understand Better.
Explore our 654-page rapid-recall book, with 38 chapters, a clickable Index and consolidated references.
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IgA Nephropathy in 2026: From Supportive Care to Mechanism-Based Treatment
How KDIGO 2025 and recent phase 3 trials are reshaping risk assessment, proteinuria targets and disease-modifying treatment in IgA nephropathy.
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Exercise Prescriptions for Cardiovascular Health: 2026 ACC Scientific Statement
An evidence-based clinical guide to prescribing exercise for cardiovascular prevention, coronary artery disease, heart failure, hypertension and other cardiovascular conditions.
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Once-Weekly Mosnodenvir Prevents Dengue Infection in 83% of Participants in Early Human Challenge Trial
In a small phase 2a DENV-3 challenge study, five of six participants in each once-weekly group had no evidence of infection; protection against naturally acquired dengue remains unproven.
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Antiplatelet Management in Coronary Syndromes: 2026 AHA Scientific Statement
Individualising antiplatelet selection, duration and de-escalation to balance thrombotic protection against bleeding risk.
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Preventive Care in Cirrhosis: 2026 ACG Clinical Guideline – A Practical Summary
A practical summary of prevention in cirrhosis, including portal hypertension, encephalopathy, infections, HCC surveillance, vaccination, nutrition and bone health.
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The 2026 Nobel Prize in Physiology or Medicine: How Light Became a Switch for the Brain
How light-gated ion channels and optogenetics transformed neuroscience, from algal proteins to precise control of neural circuits.
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2026 ADA/EASD Type 2 Diabetes Management Update: From Glucose Control to Early Organ Protection
A practical guide to the 2026 consensus: consider organ-protective treatment early, then individualise care around cardiovascular and kidney risk, weight and glycaemic goals.
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KDIGO 2027 CKD Update: Drug Therapy in CKD
New proposals for kidney and cardiovascular protection, alongside established CKD treatment. Public-review draft—not a final guideline.
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LDL-C Management in 2026: A Practical Guide to Risk-Based Targets and Treatment
Assess ASCVD risk, set an appropriate LDL-C goal, intensify treatment when needed and sustain LDL-C lowering over time.
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Nutrition to Prevent and Treat Heart Disease in 2026
Putting the 2026 ACC Scientific Statement into practice: focus on food quality, healthy substitutions and sustainable dietary patterns.
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Retatrutide: First-in-Class Triple Agonism with Benefits Beyond Weight Reduction
The phase 3 TRIUMPH-1 trial evaluated once-weekly GIP–GLP-1–glucagon triple-receptor agonism in adults with obesity without diabetes.
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2026 Pharmacological Management of MASH: Selecting, Starting and Monitoring Therapy
EASL–EASD–EASO guidance in practice: selecting eligible adults with non-cirrhotic F2–F3 MASH, choosing between resmetirom and semaglutide, and monitoring response and safety.
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Diuretics in acute heart failure with rising creatinine: continue, reduce or stop?
How to distinguish a creatinine rise during effective decongestion from one that requires a change in treatment.
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Lipoprotein(a) in Practice: Who to Test, How to Interpret It, and What to Do When It Is High
A practical approach to universal Lp(a) measurement, cardiovascular risk interpretation and management based on the 2026 National Lipid Association Lipid Simplified review.
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Non-invasive ventilation in COPD exacerbations without hypercapnic respiratory failure: when is it justified?
Distinguishing patients who need medical treatment and observation from those requiring targeted respiratory support or urgent escalation.
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Short oral corticosteroid courses in type 2 diabetes: what the 30-day safety signal means
A nationwide study links brief oral corticosteroid treatment with gastrointestinal bleeding, pneumonia and heart failure soon after initiation.
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Atenolol Outperformed Bisoprolol After MI Without Recorded Heart Failure
A French observational study found fewer major cardiovascular events with atenolol over two years—but no statistically significant mortality difference.
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SBP Prophylaxis in Cirrhosis: Who Needs Primary vs Secondary Prevention — and When Should It Be Stopped?
Long-term antibiotics can prevent spontaneous bacterial peritonitis in selected patients with cirrhosis, but treatment and withdrawal decisions require careful risk–benefit assessment.
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WHO malaria guidance 2026: diagnosis and treatment in everyday clinical practice
A practical guide to confirming malaria, assessing severity, selecting treatment, and responding safely in special populations.
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Infective endocarditis in 2026: putting the AHA scientific statement into practice
A practical approach to diagnosis, multimodality imaging, antimicrobial treatment, surgical timing and post-operative care.
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The 2026 AAN/AHS Migraine Prevention Guideline
A practical pharmacologic approach for adult migraine prevention
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Met-HeFT 2026: Metformin Failed to Reduce Cardiovascular Events in HFrEF
The randomised trial tested whether metformin provides cardiovascular protection beyond glucose lowering in HFrEF.
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What’s new in valvular heart disease?
Earlier intervention, better phenotyping and lifetime planning are reshaping aortic, mitral and tricuspid valve care.
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The 2026 ESC Cardiogenic Shock Definition
A pathophysiology-based definition centred on three essential diagnostic pillars.
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Fifth Universal Definition of Myocardial Infarction 2026: What Clinicians Need to Know
A mechanism-based framework for distinguishing myocardial infarction from myocardial injury and identifying its cause.
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Heart Failure Classification in 2026: How the ESC Guidelines and Second Universal Definition Fit Together
Understanding stages, ejection-fraction phenotypes and changing disease trajectories without forcing false equivalence.
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The 2026 ESC Guideline on Cardiovascular Disease and Chronic Kidney Disease
A practical approach to managing chronic kidney disease and cardiovascular disease together.
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The 2026 ESC Heart Failure Guideline: From Diagnosis to Advanced Heart Failure
A practical guide to classification, diagnosis, foundational therapy, decompensated HF, devices, comorbidities, advanced HF and follow-up.
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FDA Approves Brepocitinib: The First Oral Treatment for Adult Dermatomyositis
Lisraya becomes the first FDA-approved oral therapy specifically indicated for adults with dermatomyositis.
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The 2026 AHA/ASA Guideline on Adult Stroke Rehabilitation and Recovery
A practical approach to rehabilitation timing, exercise, mental health and long-term recovery.
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2026 TTP Diagnostic Pathway: A Practical Approach to Suspected Thrombotic Thrombocytopenic Purpura
A practical guide to recognising suspected TTP, collecting a pre-treatment ADAMTS13 sample, interpreting activity and antibody results, and monitoring after diagnosis.
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Corticosteroids in ARDS in 2026: Who May Benefit and When?
A practical summary of current evidence on timing, clinical setting and patient selection.
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2026 IDSA Guidance on Antimicrobial-Resistant Gram-Negative Infections
A practical guide to treating ESBL-E, AmpC-E, CRE, DTR Pseudomonas aeruginosa, CRAB and Stenotrophomonas maltophilia.
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Alcohol Intake and Lifetime Health Risk: No Net Protective Effect at Low Consumption
A US cause-specific modelling analysis estimates how weekly alcohol intake and drinking pattern relate to lifetime mortality, morbidity and injury risk.
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Acute Respiratory Failure in Adults: Choosing HFNO, NIV, CPAP or Intubation
A practical approach to selecting noninvasive respiratory support, recognising when intubation is needed and reassessing early to avoid delayed escalation.
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Acute Pancreatitis in 2026: A Practical Guide to Diagnosis, Escalation and Definitive Care
Putting the iLATAM-AP guideline into practice: reassessed fluids, early feeding, selective ERCP, infection-directed antibiotics and a step-up approach to complications.
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Single-Infusion PCSK9 Base Editing Produces Substantial LDL-C Lowering Sustained Beyond One Year
Phase 1 data suggest that one-time in-vivo PCSK9 editing can produce large and durable LDL-C reductions, although long-term safety and cardiovascular benefit remain uncertain.
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Managing Acute Asthma in 2026: A Practical Guide to the GINA Recommendations
From initial severity assessment to bronchodilator treatment, escalation, discharge and prevention of recurrent exacerbations.
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Acute pulmonary embolism in 2026: using the A–E clinical categories at the bedside
A practical guide to outpatient suitability, admission, recognition of deterioration and escalation using the 2026 AHA/ACC multisociety framework.
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Pulmonary Embolism in 2026: A Practical Approach to Diagnosis, Risk Stratification and Management
From clinical suspicion and D-dimer testing to the new AHA/ACC PE categories, anticoagulation, reperfusion therapy and follow-up.
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GOLD 2026 COPD Report: A Practical Guide to Diagnosis, Assessment and Management
What clinicians need to know about diagnosing COPD, the revised ABE assessment, initial and follow-up treatment, exacerbation prevention, biologic therapy and acute exacerbation management.
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